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Vicodin CR hydrocodone bitartrate and acetaminophen Extended Release Tablets Twice-daily Regimen Significantly Lowered Chronic Low Back Pain Intensity with 12-hour Dosing Compared to Placebo TAMPA, May 8, PRNewswire-FirstCall, - New Phase III study data showed that Abbotts investigational hydrocodone bitartrate and acetaminophen HC,APAP extended release medicine reduced pain in patients with moderate to severe chronic low back pain, one of the most common causes of chronic pain. Over 60 percent had a history of addiction treatment and had been previously admitted for psychiatric illness.