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In addition to human corpus cavernosum smooth muscle, PDE5 is also found in lower concentrations in other tissues including platelets, vascular and visceral smooth muscle, and skeletal muscle. Doses range from 25 milligrams to 100 milligrams, depending on the drug s effect. Use it cautiously-if at all-if you ve had a heart attack, stroke, or life-threatening heart irregularities within the past 6 months.
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